Principal Scientist/Associate Director - Quantitative High-Throughput Experimentation
Company: Flagship Pioneering
Posted on: June 18, 2022
About Generate Biomedicines:
GenerateBiomedicines is a new kind of therapeutics company -
existing at the intersection of machine learning, biological
engineering, and medicine - pioneering Generative Biology to create
breakthrough medicines where novel therapeutics are computationally
generated, instead of being discovered.Generatehas built a machine
learning-powered biomedicines platform with the potential
togeneratenew drugs across a wide range of biologic modalities.
This platform represents a potentially fundamental shift in what is
possible in the field of biotherapeutic development.
We pursue this audacious vision because we believe in the unique
and revolutionary power of generative biology to radically
transform the lives of billions, with an outsized opportunity for
patients in need. We are seeking collaborative, relentless problem
solvers that share our passion for impact to join us!
Generatewas founded in 2018 by Flagship Pioneering and has received
over $420 million in funding, providing the resources to rapidly
scale the organization. The Company has offices in Cambridge,
Somerville, and Andover with approximately 150 employees.
Generate is seeking a highly creative and technologically curious
Principal Scientist/Associate Director in Quantitative HTP
Experimentation to be part of the Platform Innovation Team. The
successful candidate will oversee the design and analysis of truly
novel assays at the intersection of synthetic biology,
microfluidics, automation, and Machine Learning, enabling
high-throughput data generation and interpretation throughout the
company. He/she has a proven track record of cross-disciplinary
quantitative research, combining deep understanding of biology and
high-throughput experimentation with meaningful
theoretical/statistical analysis and visualization. The successful
candidate will also play a key role in setting up our DNA
Read/Write Team and therefore has a solid understanding and
experience with NGS-based methodologies. Close collaboration with
members of Generate's Protein Science, Preclinical Discovery,
Computational, and Machine Learning teams will be crucial to
produce game-changing new biological datasets. This is an
opportunity to perform highly innovative technology development
with considerable intellectual freedom, while being part of the
collaborative and premier scientific environment of a well-funded
Responsibilities include, but are not limited to: Oversee the
development of state-of-the art high-throughput experimental
workflows to characterize biophysical and biological properties of
Optimize experimental design based on theoretical analysis,
statistics, and modeling.
Work together with members of the Platform Innovation team and
other teams to integrate micro-automation, microfluidics, and
microfabricated devices into the company's major workflows.
Play a leading role in creating Generate's DNA Read/Write Team for
NGS tech dev and library design.
Generate bold, creative, unconventional ideas, and be our team's
point person for intellectual property and patent writing.
Oversee, mentor, and train junior scientists throughout the
company. Qualifications: BSc/MSc with 10+ years or PhD+6 years of
experience in a relevant science/engineering field (physics,
biophysics, physical chemistry, biological engineering,
quantitative/synthetic biology, or related discipline).
Demonstrated expertise in implementation, analysis, and
optimization of high-throughput biological assays.
Demonstrated experience in high-throughput library design and
NGS-based assay readouts.
Experience with data analysis in Python, Matlab, R or
Have a solid quantitative mindset, a strong scientific intuition,
and a demonstrated ability to execute applied biology projects.
Experience securing intellectual property rights and patents is a
Cross-functional experience in the protein therapeutic industry is
Self-motivated and curious with a desire to learn from and teach
others. Generate Biomedicines is committed to equal employment
opportunityregardless of race, color, ancestry, religion, sex,
national origin, sexual orientation, age, citizenship, marital
status, disability, gender identity or Veteran status.
GenerateBiomedicines enforces a mandatory vaccination policy for
COVID-19. All employees must be fully vaccinated and have received
a booster. The purpose of this policy is to safeguard the health of
our employees, their families, and the community at large from
infectious disease that may be reduced by vaccinations. The company
will make exceptions to this policy if required by applicable law
and will consider requests for an exemption from this policy due to
a medical reason, or because of a sincerely held religious belief,
or any other exemptions that may be recognized by applicable
Recruitment & Staffing Agencies: Generate Biomedicines does not
accept unsolicited resumes from any source other than candidates.
The submission of unsolicited resumes by recruitment or staffing
agencies to Generate Biomedicines or its employees is strictly
prohibited unless contacted directly by Generate Biomedicines's
internal Talent Acquisition team. Any resume submitted by an agency
in the absence of a signed agreement will automatically become the
property of Generate Biomedicines, and Generate will not owe any
referral or other fees with respect thereto.
Keywords: Flagship Pioneering, Somerville , Principal Scientist/Associate Director - Quantitative High-Throughput Experimentation, Executive , Somerville, Massachusetts
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