Principal Scientist/Associate Director - Quantitative High-Throughput Experimentation

Company: Flagship Pioneering
Location: Somerville
Posted on: June 18, 2022

Job Description:

About Generate Biomedicines:
GenerateBiomedicines is a new kind of therapeutics company - existing at the intersection of machine learning, biological engineering, and medicine - pioneering Generative Biology to create breakthrough medicines where novel therapeutics are computationally generated, instead of being discovered.Generatehas built a machine learning-powered biomedicines platform with the potential togeneratenew drugs across a wide range of biologic modalities. This platform represents a potentially fundamental shift in what is possible in the field of biotherapeutic development.
We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!
Generatewas founded in 2018 by Flagship Pioneering and has received over $420 million in funding, providing the resources to rapidly scale the organization. The Company has offices in Cambridge, Somerville, and Andover with approximately 150 employees.
The Role:
Generate is seeking a highly creative and technologically curious Principal Scientist/Associate Director in Quantitative HTP Experimentation to be part of the Platform Innovation Team. The successful candidate will oversee the design and analysis of truly novel assays at the intersection of synthetic biology, microfluidics, automation, and Machine Learning, enabling high-throughput data generation and interpretation throughout the company. He/she has a proven track record of cross-disciplinary quantitative research, combining deep understanding of biology and high-throughput experimentation with meaningful theoretical/statistical analysis and visualization. The successful candidate will also play a key role in setting up our DNA Read/Write Team and therefore has a solid understanding and experience with NGS-based methodologies. Close collaboration with members of Generate's Protein Science, Preclinical Discovery, Computational, and Machine Learning teams will be crucial to produce game-changing new biological datasets. This is an opportunity to perform highly innovative technology development with considerable intellectual freedom, while being part of the collaborative and premier scientific environment of a well-funded biotech startup.
Responsibilities include, but are not limited to: Oversee the development of state-of-the art high-throughput experimental workflows to characterize biophysical and biological properties of proteins.
Optimize experimental design based on theoretical analysis, statistics, and modeling.
Work together with members of the Platform Innovation team and other teams to integrate micro-automation, microfluidics, and microfabricated devices into the company's major workflows.
Play a leading role in creating Generate's DNA Read/Write Team for NGS tech dev and library design.
Generate bold, creative, unconventional ideas, and be our team's point person for intellectual property and patent writing.
Oversee, mentor, and train junior scientists throughout the company. Qualifications: BSc/MSc with 10+ years or PhD+6 years of experience in a relevant science/engineering field (physics, biophysics, physical chemistry, biological engineering, quantitative/synthetic biology, or related discipline).
Demonstrated expertise in implementation, analysis, and optimization of high-throughput biological assays.
Demonstrated experience in high-throughput library design and NGS-based assay readouts.
Experience with data analysis in Python, Matlab, R or equivalent.
Have a solid quantitative mindset, a strong scientific intuition, and a demonstrated ability to execute applied biology projects.
Experience securing intellectual property rights and patents is a plus.
Cross-functional experience in the protein therapeutic industry is highly desired.
Self-motivated and curious with a desire to learn from and teach others. Generate Biomedicines is committed to equal employment opportunityregardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
COVID Safety:
GenerateBiomedicines enforces a mandatory vaccination policy for COVID-19. All employees must be fully vaccinated and have received a booster. The purpose of this policy is to safeguard the health of our employees, their families, and the community at large from infectious disease that may be reduced by vaccinations. The company will make exceptions to this policy if required by applicable law and will consider requests for an exemption from this policy due to a medical reason, or because of a sincerely held religious belief, or any other exemptions that may be recognized by applicable law.
Recruitment & Staffing Agencies: Generate Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate Biomedicines or its employees is strictly prohibited unless contacted directly by Generate Biomedicines's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate Biomedicines, and Generate will not owe any referral or other fees with respect thereto.

Keywords: Flagship Pioneering, Somerville , Principal Scientist/Associate Director - Quantitative High-Throughput Experimentation, Executive , Somerville, Massachusetts