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Associate Director, Comparative Pathology

Company: 2Seventy Bio
Location: Somerville
Posted on: June 18, 2022

Job Description:

At 2seventy bio, we are excited to continue leading the charge on Oncology cell therapy research. We combine our real-world clinical data from our approved multiple myeloma treatment with our tool kit of several cutting-edge technologies, dedicated partners, passionate innovators that care, and our unwavering dedication to important life-changing work. We strive to make a difference and offer more time for patients with cancer. We show up daily for our patients (literally and figuratively) and we feel privileged to be a part of their journey. If you want to challenge the status quo while having fun doing so, come be a part of this unique and exciting opportunity - we cant wait to talk to you!Join 2seventys enthusiastic and collaborative Preclinical Development team and contribute to the overall success of our novel immunotherapy and gene editing approaches. The functions of this role will include the design and evaluation of target discovery and in vivo efficacy studies and work with our clinical and regulatory teams to generate the pharmacology, toxicology and biodistribution data that is critical to translating each of bluebirds innovative therapies safely from research into patients.In this role you will join our new Oncology spinoff, 2seventy bio, where we are excited to continue leading the charge on Oncology cell therapy research. Well combine our real-world clinical data from our approved multiple myeloma treatment with our tool kit of several cutting-edge technologies, dedicated partners, passionate innovators that care, and our unwavering dedication to important life-changing work. We strive to make a difference and offer more time for patients with cancer. We show up daily for our patients (literally and figuratively) and we feel privileged to be a part of their journey. If you want to challenge the status quo while having fun doing so, come be a part of this unique and exciting opportunity - we cant wait to talk to you! About the role:Assess new targets and products for mechanism(s) of toxicity to determine clinical relevance and ways to minimize clinical impact and/or effectively position 2seventy's productsDesign and evaluate in situ hybridization, immunohistochemistry and immunofluorescence studies in support of target discovery efforts.Evaluate the clinical symptoms, clinical pathology, gross and microscopic tissue changes and changes in protein and/or mRNA expression associated with immunotherapies or gene-edited stem cell therapies.Utilize digital imaging and image analysis to provide additional objective endpoints for in vivo studies.Serve as nonclinical strategy lead for cell therapy oncology programs and as lead for the design, implementation and reporting of preclinical in vitro and in vivo immunopharmacology and/or toxicology (safety) studies to support 2seventy's clinical development programs.Work cross-functionally across the organization to ensure effective execution on nonclinical program deliverables, including with Research, CMC, Regulatory, and Clinical functions.Study results interpretation, report preparation, and support the preparation of integrated nonclinical summaries for IND/CTA filings.Be able to incorporate data into comprehensive study reports and regulatory documentsRequirements:DVM degree (or equivalent) with specialty training in veterinary pathology in the form of a pathology residencyACVP/ECVP board certification is preferredPhD in biological science, ideally in immunology, oncology, pharmacology, or toxicologyIdeally 2 to 5 years industry experience with expertise in in vivo study design and executionExperience in the nonclinical development of biotherapeutics, cell therapies, gene therapies, and gene edited products is desirable.Background and/or demonstrated skills in the practical application of investigative safety.Familiarity with regulatory guidelines to support clinical development and registrational filings would be an advantage.Comfortable working with cross-functional immunotherapy and gene therapy research teamsExperience with or willingness to learn how to supervise, train and develop junior staff2seventy bio has a mandatory vaccination policy for the COVID-19 vaccination for all employees, contractors and consultants as of January 4, 2022. In accordance with 2seventy bios duty to provide and maintain a workplace that is free of known hazards, we are adopting this policy to safeguard the health of our employees, contractors, consultants and their families, and the community at large from infections disease that may be reduced by vaccinations. Additional vaccinations beyond the Covid-19 vaccine may be added in the future. Individuals seeking an exemption from this requirement for medical or religious reasons should complete a request for accommodation form and submit the form to the human resources department. 2seventy bio may consider several factors in assessing whether an exemption is available through an interactive process. All requests for an exemption will be evaluated on an individual basis.

Keywords: 2Seventy Bio, Somerville , Associate Director, Comparative Pathology, Executive , Somerville, Massachusetts

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