Sr. Director, Head of GU Oncology Lifecycle Management

Company: Natera
Location: Boston
Posted on: February 19, 2026

Job Description:

Job Description Job Description Natera is a global leader in cell-free DNA testing focused on changing the management of disease in reproductive health, oncology, and organ transplantation. Signatera is a personalized, tumor-informed test for molecular residual disease (MRD) assessment and surveillance monitoring in patients previously diagnosed with cancer. Signatera is covered by Medicare for colorectal cancer, muscle invasive bladder cancer, high-risk breast cancer, ovarian cancer, lung cancer, and immunotherapy response monitoring for any solid tumor. As the Head of GU Oncology Lifecycle Management, you will shape the vision and strategy for Natera's oncology product portfolio in GU cancers. Your leadership will drive a cohesive, cross-functional approach—partnering with medical, sales, business development, and other key teams—to position our products effectively and address critical unmet needs in cancer care. Reporting directly to the VP of Oncology Lifecycle Management, you will own the GU disease area strategy, and make high-impact decisions to maximize the clinical and commercial success of our oncology solutions. PRIMARY RESPONSIBILITIES: Own the lifecycle planning and success of GU cancers , collaborating with cross-functional teams to develop and execute a strategic plan that drives usage, awareness, and advocacy across key stakeholders worldwide. Expand Signatera access across GU tumors – prioritize key indications, own evidence roadmaps, close evidence gaps and submit for coverage Establish tumor-specific goals to be owned by the lifecycle team and across functions. Serve as a critical member on clinical / medical teams, helping define and prioritize key indications while identifying and addressing evidence gaps. Monitor performance & mitigate risks – In close partnership with Marketing team, track performance and deliver against GU commercial and medical goals, identifying potential issues / risks and implement mitigation strategies Serve as a critical member on commercial subteams, helping to maximize Natera potential by escalating and addressing critical barriers that limit commercial adoption. Maintain a deep expertise in the GU cancers space by integrating real-time customer insights, publications, data presentations, competitive and market intelligence. Shape the value proposition for Natera's oncology products in collaboration with Medical Affairs and Commercial Marketing, leveraging clinical evidence and market dynamics. Regularly present strategic plans and progress to executive leadership. QUALIFICATIONS: Bachelor's degree, Advanced degree preferred (MBA or PhD) GU oncology market experience strongly preferred 8-10 years experience in product marketing, market analytics at a pharmaceutical / biotech company Previous KOL management experience preferred Working knowledge of oncology molecular testing / biomarkers ~25% travel required (advisory boards, congresses, sales / marketing meetings, customer meetings) KNOWLEDGE, SKILLS, AND ABILITIES: Ability to lead without authority, influence and inspire individuals Proven strategic agility with an enterprise mindset and ability to operate with executive presence Ability to partner and collaborate across a broad range of internal and external partners Strong customer orientation and focus, particularly establishing thought leader relationships Proven ability to communicate the complex simply (biomarkers, multiple indications, etc.) Strong organizational / time management skills; manage and complete multiple projects PHYSICAL DEMANDS & WORK ENVIRONMENT: Duties are typically performed in a remote home office setting. This position requires the ability to use a computer keyboard, communicate over the telephone/computer, and read printed material. Duties may require working outside normal working hours (evenings and weekends) at times. While the position may be based anywhere in the United States, availability during Pacific time hours is required. Travel required for this position: Yes: Anticipated percent for travel: ~25% travel required (advisory boards, congresses, sales / marketing meetings, customer meetings) The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations. Remote USA $1—$1 USD OUR OPPORTUNITY Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women's health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives. The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you'll work hard and grow quickly. Working alongside the elite of the industry, you'll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management. WHAT WE OFFER Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program! For more information, visit www.natera.com. Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide. All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws. If you are based in California, we encourage you to read this important information for California residents. Link: https://www.natera.com/notice -of-data-collection-california-residents/ Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes. For more information: - BBB announcement on job scams - FBI Cyber Crime resource page

Keywords: Natera, Somerville , Sr. Director, Head of GU Oncology Lifecycle Management, Executive , Boston, Massachusetts