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Molecular Engineering Lead, Global Gene Therapy Research

Company: Takeda Pharmaceutical
Location: Somerville
Posted on: May 13, 2022

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's and . I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionAre you looking for a patient-focused company that enables transformative technologies to address patients' needs while inspiring you and support your career? Takeda is a world-class organization where we combine our expertise in disease biology, modality technologies and drug development experience to develop gene therapies in a holistic approach. We are seeking a highly motivated leader with substantial experience in vector design and gene therapy drug development experience to join Takeda to advance our gene therapy research effort. Be empowered and join us as a Molecular Engineering Lead in the Global Gene Therapy Research Team.Objectives:As the Gene Therapy Molecular Engineering Lead, you will provide expertise in the understanding and manipulations of multiple types of regulatory elements and its use in Gene Therapy research projects for research and development purposes.Accountabilities:

  • Use in silico tools, design nucleic acid sequences (eg. transgenes, regulatory elements) with properties that would be incorporated into gene therapy product candidates.
  • Order and provide technical and logistical oversight to CROs that produces the nucleic acid material and DNA sequencing analysis with acceptable quality.
  • Perform hands-on design of assays, internally in our research lab And through appropriate CROs to test and characterize DNA/RNA sequence in the gene therapy context.
  • Understand the design and assemble of viral and no-viral vectors for gene therapy application.
  • Identification and testing of DNA elements (cis/trans) to gene therapy applications.
  • Design and optimized library preparation and coordinate Vector Integration Site analysis internally and with CRO.
  • Collaborate within Global Gene Therapy sub-functions, and other technology platform teams and Drug Discovery Units to support both gene therapy therapeutic and technology projects.
  • Follow compliance of documentation in electronic lab notebook and author scientific reports that supports internal documentation and regulatory submissions.
  • Demonstrate good organizational and communication skills. Expected to be accountable for effectiveness and timelines of completion of project goals.EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS :
    • PhD degree in a scientific discipline, or MS with 6+ years relevant experience
    • Hands-on direct experiences in handling molecular biology cloning, DNA sequence synthesis through CROs, DNA extraction for nucleic acid analysis and publication record to demonstrate this ability is preferred.
    • Expertise using molecular software (SnapGene, Vector NTI, Geneious Prime, or others) to analyze and build DNA constructs.
    • Previous experience in silico genomic DNA and RNA search from available databases, analysis, annotation, interpretation and organize results with visualization that could be presented and communicated.
    • Experience using viral and non-viral technology for gene delivery.
    • Experience with library preparation and integration assay.
    • Experience using different transfection methods for mammalian cells.
    • Microbiology knowledge and skills (E. coli culture, transformation, plasmid extraction)
    • Proficiency in mammalian cell culture and aseptic cell culture techniques
    • Analyze data to provide an interpretation of results with appropriate biostatistical analysis.
    • Ability to balance multiple projects under demanding timelineIn accordance with the CO Equal Pay Act, -Colorado Applicants Are Not Permitted to Apply.Absent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. US field-based employees must be fully vaccinated as a condition of employment, absent an approved religious or medical reason. US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. If you are contacted by a Takeda recruiter about your job application, we encourage you to seek more information on the applicable guidelines for the Business Unit/Function to which you have applied.Employee may also be eligible for Short-term and Long-term incentive benefits. Employees are eligible to participate in Medical, Dental. Vision, Life Insurance, 401(k), Charitable Contribution Match, Company Holidays, Personal & Vacation Days, Student Loan Repayment Program and Paid Volunteer Time Off. If candidate is not eligible for any benefits or other comp., those can be excluded.EEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsUSA - MA - Cambridge - Binney StWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time

Keywords: Takeda Pharmaceutical, Somerville , Molecular Engineering Lead, Global Gene Therapy Research, Healthcare , Somerville, Massachusetts

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