Research Scientist I - Klarman Cell Observatory (KCO)

Company: Broad Institute
Location: Somerville
Posted on: January 5, 2021

Job Description:

Job DescriptionOVERALL RESPONSIBILITYThe Broad Institute of MIT and Harvard is the world---s leading biomedical research institute dedicated to the bold mission of using the full power of genomics to transform the understanding and treatment of disease. The Broad Institute seeks to describe all of the molecular components of life and their connections; discover the molecular basis of major human diseases; develop effective new approaches to diagnostics and therapeutics; and disseminate discoveries, tools, methods, and data openly to the entire scientific community.The position resides within the Klarman Cell Observatory (KCO) which is an effort to systematically define cellular circuits within and between cells in tissues to better understand health and disease. It builds on breakthrough technologies, such as single cell genomics, and on a network of collaborations that cut across scientific disciplines such as immunology, neuroscience and cancer. The research scientist will direct data generation for projects aimed at characterizing the human microbiome and analysis of its role in human health and disease. Responsibilities center on the development, optimization, and systematic application of cutting-edge methods for generating high-throughput sequencing data to address key questions relating to infectious disease and the human microbiome. The candidate will work independently as well as with team management and scientific staff in a highly dynamic research environment. The candidate will be encouraged to use their creativity and initiative to develop, optimize, and execute a variety of protocols, helping to coordinate and ensure the timely completion of goals for diverse projects. The research scientist will serve as a primary contact between external investigators and internal staff, communicating and coordinating on the design and progress of projects.CHARACTERISTIC DUTIESOversees data generation and data analysis across various internal and external collaborationsCollaborates with managers and scientific staff to successfully complete KCO goals, including DNA and RNA extraction and library design, construction, and testing for next-generation sequencing.Responsible for acquiring the in-depth knowledge and hands-on expertise in all required molecular biology procedures. Demonstrates flexibility to execute tasks requiring various skill levels.Performs analyses of current processes and identifies opportunities for improvement. Proposes and evaluates changes in procedures to ensure output of high-quality data.Works towards continuous technology development; collaborates with internal and external technology development teamsResponsible for high-quality execution of production projects, working with other team members and leadership to plan project requirements and timelines. Identifies and helps solve methodological problems and adjusts experimental protocols to ensure successful project completion in a timely fashion.Interacts and coordinates with vendors to address and investigate novel molecular biology reagents, techniques and equipment.Compiles and analyzes all experimental data in a timely fashion, and adjusts design as necessary. Discusses problems with team Manager in a timely manner.Mentor and manage junior scientists to ensure quality and rigor of science.Administers and recommends changes to policies and procedures which affect the groupOther related tasks as required by Manager.QUALIFICATIONSEducationQualified candidates should possess a PhD in microbiology, biochemistry, cell/molecular biology, or related field, with at least 5 years of research experience (can be concurrent with the graduate degree).RequirementsMinimum of 5 years of relevant professional experience in a molecular biology environment required. Experience in a high-throughput laboratory a plus.Solid knowledge of DNA cloning and PCR is preferred.Solid knowledge of RNA approaches (RNA-Seq) is preferred.Excellent experimental skills and a strong background in the latest molecular biology and genomics methodologies a must.Excellent critical thinking and analytical skills required.Must have exceptional organizational skills.Excellent communication and interpersonal skills and the ability to interact with multidisciplinary staff in a fast-paced environment required.Must have experience that demonstrates the ability to carry out a variety of tasks in parallel, recognize and solve problems effectively, and shift priorities rapidly.Must have excellent staff oversight and mentoring skillsCreativity, curiosity, and the desire, persistence and ability to create scientific advancesLI-POSTAll qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.EEO is The Law - click here for more informationEqual Opportunity Employer Minorities/Women/Protected Veterans/DisabledCheck out this video for a look into our communityJob InfoType: Full timeLocation: Cambridge, MA

Keywords: Broad Institute, Somerville , Research Scientist I - Klarman Cell Observatory (KCO), Other , Somerville, Massachusetts