Senior Research Investigator, Mechanisms of Cancer Resistance (MoCR)
Company: Bristol Myers Squibb
Location: Somerville
Posted on: January 6, 2021
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Job Description:
At Bristol Myers Squibb, we are inspired by a single vision ---
transforming patients--- lives through science. In oncology,
hematology, immunology and cardiovascular disease --- and one of
the most diverse and promising pipelines in the industry --- each
of our passionate colleagues contribute to innovations that drive
meaningful change. We bring a human touch to every treatment we
pioneer. Join us and make a difference.The new Bristol-Myers Squibb
research site in Cambridge---s Kendall Square will help us continue
to deliver on our mission, positioning the company and our
scientists in the heart of a vibrant ecosystem of world-class
science, innovation and business opportunities. The Mechanisms of
Cancer Resistance Thematic Research Center at BMS is one of the
fundamental research and early development engines delivering
oncology therapeutics to patients. The scientists at this
state-of-the-art research and development site in Cambridge focus
on novel tumor intrinsic targets and pathways for tumors that are
refractory to current Immuno-Oncology and Oncology therapies, and
implement our discovery platforms across all of our therapeutic
areas of focus. We are a fully integrated drug discovery through
translational and early clinical development organization which
exploits state-of-the-art in vitro, in vivo and ex-vivo models of
cancer biology to identify and validate targets. We partner closely
with colleagues in Translational Medicine, Informatics and
Predictive Sciences and Early Clinical Development to generate
biomarker and patient enrichment hypotheses to enable efficient
decision making in early clinical trials. We are optimally
positioned to complement the world-class translational expertise,
biology and leading academic research centers in the area. Senior
Research Investigator (Drug Discovery)Job DescriptionThis Senior
Research Investigator Drug Discovery will join the Cancer
Resistance Biology Research Team at Bristol-Myers Squibb in
Cambridge, MA to support preclinical drug discovery and development
against therapeutic targets at the intersection of intrinsic tumor
genetics and the extrinsic tumor microenvironment. The qualified
candidate is a highly motivated, interactive, and creative
individual who possesses substantial experience in studying tumor
biology and genetics, and experience or strong interest as to how
these features impact immune responses to the tumor. Since BMS is a
matrixed organization, the candidate will be expected to
effectively collaborate with colleagues in supportive line
functions (including oncology, immuno-oncology and immunology,
medicinal chemistry, candidate optimization and translational
medicine) to advance preclinical development of therapeutic
candidates to early clinical development. The successful candidate
will demonstrate clear and professional verbal and written
communication, capable of presenting scientific results to
multidisciplinary teams, senior management and at external
scientific meetings. The candidate will develop external
partnerships/collaborations to advance internal programs, as
appropriate. S/he will also manage a small in vitro biology lab to
support their project responsibilities as well as to contribute to
team held objectives, including new project and target ideas. This
position is located in Cambridge, MA. There will be less than
10-20% travel.QualificationsRequiredA Ph.D. degree with a minimum
of 4 of relevant experience in cancer biology and genetics,
immnuo-oncology or a closely related fieldIndustry experience with
demonstrated abilities to drive preclinical development from target
ID to clinical candidate selection, especially experience in small
molecule drug discovery. Demonstrated expertise to independently
apply bioinformatics and data mining through multi-variate
analysis; ability to effectively interact with core bioinformatics
colleagues, as well as to use desktop tools/interfaces (e.g.,
Oncoland, Wuxi) and public databases (CBIO, Achilles,
etc.)Excellent oral and written communication skills, as is the
ability to effectively present scientific data and concepts to
international standards. PreferredExperience or the ability to
innovate in novel preclinical in vitro, in vivo and ex vivo
oncology model development that enables bridging from tumor biology
to host immunity is highly desired. Management/supervisory
experienceReports 2-3 Research Scientists/AssociatesAround the
world, we are passionate about making an impact on the lives of
patients with serious diseases. Empowered to apply our individual
talents and diverse perspectives in an inclusive culture, our
shared values of passion, innovation, urgency, accountability,
inclusion and integrity bring out the highest potential of each of
our colleagues.Bristol Myers Squibb recognizes the importance of
balance and flexibility in our work environment. We offer a wide
variety of competitive benefits, services and programs that provide
our employees with the resources to pursue their goals, both at
work and in their personal lives.Full time
Keywords: Bristol Myers Squibb, Somerville , Senior Research Investigator, Mechanisms of Cancer Resistance (MoCR), Other , Somerville, Massachusetts
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