Senior Research Investigator, Mechanisms of Cancer Resistance (MoCR)

Company: Bristol Myers Squibb
Location: Somerville
Posted on: January 6, 2021

Job Description:

At Bristol Myers Squibb, we are inspired by a single vision --- transforming patients--- lives through science. In oncology, hematology, immunology and cardiovascular disease --- and one of the most diverse and promising pipelines in the industry --- each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.The new Bristol-Myers Squibb research site in Cambridge---s Kendall Square will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation and business opportunities. The Mechanisms of Cancer Resistance Thematic Research Center at BMS is one of the fundamental research and early development engines delivering oncology therapeutics to patients. The scientists at this state-of-the-art research and development site in Cambridge focus on novel tumor intrinsic targets and pathways for tumors that are refractory to current Immuno-Oncology and Oncology therapies, and implement our discovery platforms across all of our therapeutic areas of focus. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of cancer biology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area. Senior Research Investigator (Drug Discovery)Job DescriptionThis Senior Research Investigator Drug Discovery will join the Cancer Resistance Biology Research Team at Bristol-Myers Squibb in Cambridge, MA to support preclinical drug discovery and development against therapeutic targets at the intersection of intrinsic tumor genetics and the extrinsic tumor microenvironment. The qualified candidate is a highly motivated, interactive, and creative individual who possesses substantial experience in studying tumor biology and genetics, and experience or strong interest as to how these features impact immune responses to the tumor. Since BMS is a matrixed organization, the candidate will be expected to effectively collaborate with colleagues in supportive line functions (including oncology, immuno-oncology and immunology, medicinal chemistry, candidate optimization and translational medicine) to advance preclinical development of therapeutic candidates to early clinical development. The successful candidate will demonstrate clear and professional verbal and written communication, capable of presenting scientific results to multidisciplinary teams, senior management and at external scientific meetings. The candidate will develop external partnerships/collaborations to advance internal programs, as appropriate. S/he will also manage a small in vitro biology lab to support their project responsibilities as well as to contribute to team held objectives, including new project and target ideas. This position is located in Cambridge, MA. There will be less than 10-20% travel.QualificationsRequiredA Ph.D. degree with a minimum of 4 of relevant experience in cancer biology and genetics, immnuo-oncology or a closely related fieldIndustry experience with demonstrated abilities to drive preclinical development from target ID to clinical candidate selection, especially experience in small molecule drug discovery. Demonstrated expertise to independently apply bioinformatics and data mining through multi-variate analysis; ability to effectively interact with core bioinformatics colleagues, as well as to use desktop tools/interfaces (e.g., Oncoland, Wuxi) and public databases (CBIO, Achilles, etc.)Excellent oral and written communication skills, as is the ability to effectively present scientific data and concepts to international standards. PreferredExperience or the ability to innovate in novel preclinical in vitro, in vivo and ex vivo oncology model development that enables bridging from tumor biology to host immunity is highly desired. Management/supervisory experienceReports 2-3 Research Scientists/AssociatesAround the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.Full time

Keywords: Bristol Myers Squibb, Somerville , Senior Research Investigator, Mechanisms of Cancer Resistance (MoCR), Other , Somerville, Massachusetts