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Principal Scientist, Process Sciences

Company: Alnylam Pharmaceuticals
Location: Somerville
Posted on: January 12, 2021

Job Description:

Job Description - Principal Scientist, Process Sciences (TOQA2019R1044)Job Description Principal Scientist, Process Sciences(Job Number: TOQA2019R1044)Description Principal Scientist, Process SciencesOverviewAlnylam is the world---s leading RNA interference (RNAi) company.Founded in 2002, Alnylam was built upon a bold vision of turning scientific possibility into reality by harnessing the power of RNAi for human health as an innovative new class of medicines. We are a growing biopharmaceutical company with two approved medicines and a robust pipeline of investigational medicines focused in four strategic therapeutic areas: genetic medicines, cardio-metabolic diseases, infectious diseases, and central nervous system (CNS) and ocular diseases, including several in late-stage development. Headquartered in Cambridge, Mass., Alnylam employs over 1,400 people in 19 countries and is rapidly growing globally, with additional offices in Norton, Mass., Maidenhead, U.K., Zug, Switzerland, Amsterdam, Netherlands, and Tokyo, Japan. Alnylam is proud to have been recognized as one of The Boston Globe---s Top Places to Work five years in a row (2015-2019), a Great Place to Work in the U.K. and Switzerland in 2020 and Science Magazine---s 1 Top Employer in 2019. Please visit for more information.The successful candidate will be a part of the Process and Analytical Sciences group. Responsibilities will include process development, in-house non-GMP manufacturing process transfer to CMOs, and stage 1 manufacturing process validation for siRNA oligonucleotides.Summary of Key ResponsibilitiesLeading oligonucleotide manufacturing process development, optimization and scale upParticipating in in-process analytical method development and optimizationManaging oligonucleotide APIs manufacture in non-GMP environmentAuthoring process description, technical protocols and reports. Leading process transfer activities and providing timely technical support for GMP productions.Drafting/Reviewing SOPs and manufacturing documents according to regulatory and procedural guidelines. Supporting process characterization activities.Working closely with manufacturing, AD/QC, QA teams and CMO/CRO in GMP manufacture and other CMC activitiesDay-to-day lab operations and equipment maintenance QualificationsPh.D. with 5-7 years of experience in oligonucleotide chemistry or relevant areas. Experience in industrial settings is preferredExpertise in solid-phase synthesis and hands-on operational knowledge with DNA/RNA automated solid-phase synthesizers is required.Thorough understanding of process development approaches. Ability to integrate scientific findings/results across multiple areas of research or development projects.Knowledge of the analytical and purification techniques for oligonucleotides, and oligonucleotide-conjugates is preferred.Good verbal and written communication skills are a mustAlnylam Pharmaceuticals is an EEO employer committed to an exciting, diverse, and enriching work environment.LI-CF1

Keywords: Alnylam Pharmaceuticals, Somerville , Principal Scientist, Process Sciences, Other , Somerville, Massachusetts

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