Principal Scientist, Process Sciences
Company: Alnylam Pharmaceuticals
Location: Somerville
Posted on: January 12, 2021
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Job Description:
Job Description - Principal Scientist, Process Sciences
(TOQA2019R1044)Job Description Principal Scientist, Process
Sciences(Job Number: TOQA2019R1044)Description Principal Scientist,
Process SciencesOverviewAlnylam is the world---s leading RNA
interference (RNAi) company.Founded in 2002, Alnylam was built upon
a bold vision of turning scientific possibility into reality by
harnessing the power of RNAi for human health as an innovative new
class of medicines. We are a growing biopharmaceutical company with
two approved medicines and a robust pipeline of investigational
medicines focused in four strategic therapeutic areas: genetic
medicines, cardio-metabolic diseases, infectious diseases, and
central nervous system (CNS) and ocular diseases, including several
in late-stage development. Headquartered in Cambridge, Mass.,
Alnylam employs over 1,400 people in 19 countries and is rapidly
growing globally, with additional offices in Norton, Mass.,
Maidenhead, U.K., Zug, Switzerland, Amsterdam, Netherlands, and
Tokyo, Japan. Alnylam is proud to have been recognized as one of
The Boston Globe---s Top Places to Work five years in a row
(2015-2019), a Great Place to Work in the U.K. and Switzerland in
2020 and Science Magazine---s 1 Top Employer in 2019. Please visit
for more information.The successful candidate will be a part of the
Process and Analytical Sciences group. Responsibilities will
include process development, in-house non-GMP manufacturing process
transfer to CMOs, and stage 1 manufacturing process validation for
siRNA oligonucleotides.Summary of Key ResponsibilitiesLeading
oligonucleotide manufacturing process development, optimization and
scale upParticipating in in-process analytical method development
and optimizationManaging oligonucleotide APIs manufacture in
non-GMP environmentAuthoring process description, technical
protocols and reports. Leading process transfer activities and
providing timely technical support for GMP
productions.Drafting/Reviewing SOPs and manufacturing documents
according to regulatory and procedural guidelines. Supporting
process characterization activities.Working closely with
manufacturing, AD/QC, QA teams and CMO/CRO in GMP manufacture and
other CMC activitiesDay-to-day lab operations and equipment
maintenance QualificationsPh.D. with 5-7 years of experience in
oligonucleotide chemistry or relevant areas. Experience in
industrial settings is preferredExpertise in solid-phase synthesis
and hands-on operational knowledge with DNA/RNA automated
solid-phase synthesizers is required.Thorough understanding of
process development approaches. Ability to integrate scientific
findings/results across multiple areas of research or development
projects.Knowledge of the analytical and purification techniques
for oligonucleotides, and oligonucleotide-conjugates is
preferred.Good verbal and written communication skills are a
mustAlnylam Pharmaceuticals is an EEO employer committed to an
exciting, diverse, and enriching work environment.LI-CF1
Keywords: Alnylam Pharmaceuticals, Somerville , Principal Scientist, Process Sciences, Other , Somerville, Massachusetts
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