DMPK Modeling and Simulation Scientist
Company: Yoh, A Day & Zimmermann Company
Location: Somerville
Posted on: January 15, 2021
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Job Description:
DMPK Modeling and Simulation Scientist (Investigator II/Senior
Investigator)
Our client is a leading company in cancer genomics driven drug
discovery, delivering on the promise of precision medicine. The
company was launched in 2011 with an unprecedented $200 million in
initial funding, plus a continued ongoing commitment to fund our
client's robust discovery pipeline and clinical programs. Now with
three clinical stage anti-cancer molecules in active development,
our client is able to uniquely leverage distinct insights from
cancer genomics and real-life patient data to advance its projects
to clinical proof of concept and beyond. Our client embraces a
novel business model in which it collaborates with Eisai, a leading
global pharmaceutical company, to create a prolific drug discovery
engine and partnership platform.
The client's modeling and simulation scientist will be primarily
responsible to deliver a quantitative and mechanistic understanding
of PK/PD/efficacy relationships to support project teams from early
discovery through early clinical development.
In addition, the individual will be involved in the design,
execution, analysis, interpretation and communication of
pharmacokinetics (PK) and absorption, distribution, metabolism, and
excretion (ADME) studies of to support drug development from early
discovery through preclinical and clinical development. The
individual will serve as DMPK project representative to coordinate
and lead all nonclinical DMPK activities on programs from the
research phase through development. An individual with in-depth
knowledge and expertise in PK/PD modeling and simulation and ADME
would be essential.
Principal Duties and Responsibilities:
Deliver a quantitative and mechanistic understanding of
PK/PD/efficacy relationships to support drug discovery and
development teams
Design and execute preclinical studies to understand the
pharmacokinetics (PK) and absorption, metabolism, distribution, and
excretion (ADME) of drug candidates
Represent DMPK as the subject matter expert to the project teams,
develop and drive DMPK and PK/PD strategy for Drug Discovery
projects
Responsible for the analysis, interpretation, integration and
reporting of preclinical DMPK data generated both internally and
with external vendors
Participate in the management of CROs in the conduct of in vitro/in
vivo ADME studies
Partner with and support Drug Safety, Research, Clinical,
Regulatory, Project Management and other departments
Qualifications
PhD. in Pharmacokinetics, Pharmacology, Pharmaceutics or other
relevant field with 5 years of experience in the biopharmaceutical
industry preferred, or MS/BS with 5 years' industry experience,
including evidence of modeling and simulation experience
Conceptual fluency with modeling, and in depth hands-on modeling
experience (e.g. using WinNonlin Phoenix, MATLAB/Simbiology, PK
Sim, Simcyp, or, background using NONMEM to develop PK/PD
models)
Strong knowledge of drug metabolism, ADME concepts,
pharmacokinetics, pharmacodynamic and bioanalytical principles is
required.
Experience with biologics desirable but not required.
Strong communication (verbal and written) and presentation skills
required
Excellent interpersonal skills and ability to represent DMPK in a
team environment are essential
DMPK Modeling and Simulation Scientist (Investigator II/Senior
Investigator)
Our client is a leading company in cancer genomics driven drug
discovery, delivering on the promise of precision medicine. The
company was launched in 2011 with an unprecedented $200 million in
initial funding from Eisai, plus a continued ongoing commitment to
fund our client's robust discovery pipeline and clinical programs.
Now with three clinical stage anti-cancer molecules in active
development, our client is able to uniquely leverage distinct
insights from cancer genomics and real-life patient data to advance
its projects to clinical proof of concept and beyond. Our client
embraces a novel business model in which it collaborates with
Eisai, a leading global pharmaceutical company, to create a
prolific drug discovery engine and partnership platform.
The client's modeling and simulation scientist will be primarily
responsible to deliver a quantitative and mechanistic understanding
of PK/PD/efficacy relationships to support project teams from early
discovery through early clinical development.
In addition, the individual will be involved in the design,
execution, analysis, interpretation and communication of
pharmacokinetics (PK) and absorption, distribution, metabolism, and
excretion (ADME) studies of to support drug development from early
discovery through preclinical and clinical development. The
individual will serve as DMPK project representative to coordinate
and lead all nonclinical DMPK activities on programs from the
research phase through development. An individual with in-depth
knowledge and expertise in PK/PD modeling and simulation and ADME
would be essential.
Principal Duties and Responsibilities:
Deliver a quantitative and mechanistic understanding of
PK/PD/efficacy relationships to support drug discovery and
development teams
Design and execute preclinical studies to understand the
pharmacokinetics (PK) and absorption, metabolism, distribution, and
excretion (ADME) of drug candidates
Represent DMPK as the subject matter expert to the project teams,
develop and drive DMPK and PK/PD strategy for Drug Discovery
projects
Responsible for the analysis, interpretation, integration and
reporting of preclinical DMPK data generated both internally and
with external vendors
Participate in the management of CROs in the conduct of in vitro/in
vivo ADME studies
Partner with and support Drug Safety, Research, Clinical,
Regulatory, Project Management and other departments
Qualifications
PhD. in Pharmacokinetics, Pharmacology, Pharmaceutics or other
relevant field with 5 years of experience in the biopharmaceutical
industry preferred, or MS/BS with 5 years' industry experience,
including evidence of modeling and simulation experience
Conceptual fluency with modeling, and in depth hands-on modeling
experience (e.g. using WinNonlin Phoenix, MATLAB/Simbiology, PK
Sim, Simcyp, or, background using NONMEM to develop PK/PD
models)
Strong knowledge of drug metabolism, ADME concepts,
pharmacokinetics, pharmacodynamic and bioanalytical principles is
required.
Experience with biologics desirable but not required.
Strong communication (verbal and written) and presentation skills
required
Excellent interpersonal skills and ability to represent DMPK in a
team environment are essential
Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer.
All qualified applicants will receive consideration for employment
without regard to race, color, religion, sex, sexual orientation,
gender identity, national origin, disability, or status as a
protected veteran. Visit
https://www.yoh.com/applicants-with-disabilities to contact us if
you are an individual with a disability and require accommodation
in the application process.PandoLogic.Category: General
Keywords: Yoh, A Day & Zimmermann Company, Somerville , DMPK Modeling and Simulation Scientist, Other , Somerville, Massachusetts
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