DMPK Modeling and Simulation Scientist

Company: Yoh, A Day & Zimmermann Company
Location: Somerville
Posted on: January 15, 2021

Job Description:

DMPK Modeling and Simulation Scientist (Investigator II/Senior Investigator)




Our client is a leading company in cancer genomics driven drug discovery, delivering on the promise of precision medicine. The company was launched in 2011 with an unprecedented $200 million in initial funding, plus a continued ongoing commitment to fund our client's robust discovery pipeline and clinical programs. Now with three clinical stage anti-cancer molecules in active development, our client is able to uniquely leverage distinct insights from cancer genomics and real-life patient data to advance its projects to clinical proof of concept and beyond. Our client embraces a novel business model in which it collaborates with Eisai, a leading global pharmaceutical company, to create a prolific drug discovery engine and partnership platform.

The client's modeling and simulation scientist will be primarily responsible to deliver a quantitative and mechanistic understanding of PK/PD/efficacy relationships to support project teams from early discovery through early clinical development.

In addition, the individual will be involved in the design, execution, analysis, interpretation and communication of pharmacokinetics (PK) and absorption, distribution, metabolism, and excretion (ADME) studies of to support drug development from early discovery through preclinical and clinical development. The individual will serve as DMPK project representative to coordinate and lead all nonclinical DMPK activities on programs from the research phase through development. An individual with in-depth knowledge and expertise in PK/PD modeling and simulation and ADME would be essential.

Principal Duties and Responsibilities:


Deliver a quantitative and mechanistic understanding of PK/PD/efficacy relationships to support drug discovery and development teams
Design and execute preclinical studies to understand the pharmacokinetics (PK) and absorption, metabolism, distribution, and excretion (ADME) of drug candidates
Represent DMPK as the subject matter expert to the project teams, develop and drive DMPK and PK/PD strategy for Drug Discovery projects
Responsible for the analysis, interpretation, integration and reporting of preclinical DMPK data generated both internally and with external vendors
Participate in the management of CROs in the conduct of in vitro/in vivo ADME studies
Partner with and support Drug Safety, Research, Clinical, Regulatory, Project Management and other departments


Qualifications


PhD. in Pharmacokinetics, Pharmacology, Pharmaceutics or other relevant field with 5 years of experience in the biopharmaceutical industry preferred, or MS/BS with 5 years' industry experience, including evidence of modeling and simulation experience
Conceptual fluency with modeling, and in depth hands-on modeling experience (e.g. using WinNonlin Phoenix, MATLAB/Simbiology, PK Sim, Simcyp, or, background using NONMEM to develop PK/PD models)
Strong knowledge of drug metabolism, ADME concepts, pharmacokinetics, pharmacodynamic and bioanalytical principles is required.
Experience with biologics desirable but not required.
Strong communication (verbal and written) and presentation skills required
Excellent interpersonal skills and ability to represent DMPK in a team environment are essential





DMPK Modeling and Simulation Scientist (Investigator II/Senior Investigator)




Our client is a leading company in cancer genomics driven drug discovery, delivering on the promise of precision medicine. The company was launched in 2011 with an unprecedented $200 million in initial funding from Eisai, plus a continued ongoing commitment to fund our client's robust discovery pipeline and clinical programs. Now with three clinical stage anti-cancer molecules in active development, our client is able to uniquely leverage distinct insights from cancer genomics and real-life patient data to advance its projects to clinical proof of concept and beyond. Our client embraces a novel business model in which it collaborates with Eisai, a leading global pharmaceutical company, to create a prolific drug discovery engine and partnership platform.

The client's modeling and simulation scientist will be primarily responsible to deliver a quantitative and mechanistic understanding of PK/PD/efficacy relationships to support project teams from early discovery through early clinical development.

In addition, the individual will be involved in the design, execution, analysis, interpretation and communication of pharmacokinetics (PK) and absorption, distribution, metabolism, and excretion (ADME) studies of to support drug development from early discovery through preclinical and clinical development. The individual will serve as DMPK project representative to coordinate and lead all nonclinical DMPK activities on programs from the research phase through development. An individual with in-depth knowledge and expertise in PK/PD modeling and simulation and ADME would be essential.

Principal Duties and Responsibilities:


Deliver a quantitative and mechanistic understanding of PK/PD/efficacy relationships to support drug discovery and development teams
Design and execute preclinical studies to understand the pharmacokinetics (PK) and absorption, metabolism, distribution, and excretion (ADME) of drug candidates
Represent DMPK as the subject matter expert to the project teams, develop and drive DMPK and PK/PD strategy for Drug Discovery projects
Responsible for the analysis, interpretation, integration and reporting of preclinical DMPK data generated both internally and with external vendors
Participate in the management of CROs in the conduct of in vitro/in vivo ADME studies
Partner with and support Drug Safety, Research, Clinical, Regulatory, Project Management and other departments


Qualifications


PhD. in Pharmacokinetics, Pharmacology, Pharmaceutics or other relevant field with 5 years of experience in the biopharmaceutical industry preferred, or MS/BS with 5 years' industry experience, including evidence of modeling and simulation experience
Conceptual fluency with modeling, and in depth hands-on modeling experience (e.g. using WinNonlin Phoenix, MATLAB/Simbiology, PK Sim, Simcyp, or, background using NONMEM to develop PK/PD models)
Strong knowledge of drug metabolism, ADME concepts, pharmacokinetics, pharmacodynamic and bioanalytical principles is required.
Experience with biologics desirable but not required.
Strong communication (verbal and written) and presentation skills required
Excellent interpersonal skills and ability to represent DMPK in a team environment are essential





Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran. Visit https://www.yoh.com/applicants-with-disabilities to contact us if you are an individual with a disability and require accommodation in the application process.PandoLogic.Category: General

Keywords: Yoh, A Day & Zimmermann Company, Somerville , DMPK Modeling and Simulation Scientist, Other , Somerville, Massachusetts