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Associate Director/Director Discovery Toxicology

Company: Takeda
Location: Somerville
Posted on: May 3, 2021

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's Privacy Noticeand Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionAre you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. We endeavor to build an industry-leading Discovery Toxicology program at Takeda. Become a vital contributor to our inspiring, bold mission by joining as a Discovery Toxicologist in our Cambridge, MA office.Our ideal candidate will have a proven track record in prominent roles supporting cross-functional Discovery teams. She/he is able to leverage their deep insights into cellular and pathway mechanisms, coupled with knowledge of toxicology in order to provide expert advice and direction to improve the quality of therapeutics. An emphasis in the field of Rare Diseases or Immunology as well as experience in gene therapy or oligonucleotide therapy would be a strong plus.OBJECTIVESAs part of the Global Discovery Toxicology Team work in interdisciplinary teams within and across Global Safety to provide safety support to early discovery teams in Rare Diseases and Immuno-oncology and engage in core activities within the Discovery Toxicology groupWork as part of a team of safety assessment scientists and more broadly DMPK, pathology, pharmacology, and medicinal chemistry experts to implement discovery toxicology strategy to enable the selection and progression of optimized drug candidatesApply novel toxicity mechanism-based assays and integrated models to support early target safety and chemistry evaluation. Additional responsibilities include leading or supporting inter- and intra-departmental initiatives.ACCOUNTABILITIESProvide pharmaceutical drug project teams with expert advice and direction to improve the quality of therapeutics selected for further development based on proactive risk assessment of target- and chemotype-related toxicitiesDevelop comprehensive target safety reviews with risk mitigation plan for early drug discovery project teams based on literature, bioinformatics, and other predictive tools.Apply state of the art in silico, in vitro, and in vivo de-risking strategies to aid in the selection and optimization of large and small molecule therapeutics, as well as new therapeutic modalitiesLead the development of early hypothesis-driven investigation into mechanisms of toxicity for the proactive management of potential safety liabilities and communication of impact to teamsEDUCATION, BEHAVIORAL COMPETENCIES AND SKILLSMinimum of MS/PharmD with 15+ years of pharmaceutical experience or PhD in a scientific discipline and 10+ years of experience working at a pharmaceutical companyDemonstrated project team experience at a pharmaceutical company and ability to work effectively in a matrix, global environment as part of a multidisciplinary teamStrong problem solver who is highly organized with the ability to thrive in an environment with rapidly changing priorities.Passion to decrease safety related attrition in drug discoveryBroad scientific knowledge including pharmacology, toxicology, physiology and biochemistry.Experience in development across mixed modalities, especially oligonucleotides and gene therap and an extensive knowledge in rare diseases, immunology, and/or oncology is desired.Strong interpersonal skills with an ability to develop solid, long term relationships and the ability to influence others, and adept at working across multiple cross-functional areas.Excellent oral and written communication skillsDABT certification a plus, but not necessaryThis job posting excludes CO applicantsWHAT TAKEDA CAN OFFER YOU: 401(k) with company match and Annual Retirement Contribution PlanTuition reimbursement Company match of charitable contributionsHealth & Wellness programs including onsite flu shots and health screeningsGenerous time off for vacation and the option to purchase additional vacation daysCommunity Outreach ProgramsEmpowering Our People to ShineDiscover more at No Phone Calls or Recruiters Please.#LI-KL1LocationsCambridge, MAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull timeJob InfoType: Full timeLocation: Cambridge, MASDL2017

Keywords: Takeda, Somerville , Associate Director/Director Discovery Toxicology, Other , Somerville, Massachusetts

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