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Engineer III/Senior Engineer I

Company: Biogen Idec
Location: Somerville
Posted on: May 3, 2021

Job Description:

Job DescriptionWe are seeking a highly motivated and creative individual with bioprocess engineering experience to join our Cell Culture Development team. This position provides an exciting opportunity to develop robust, highly productive cell culture processes for production of recombinant protein biologics. We are looking for someone who is passionate for exploring novel scientific ideas and play a key role in developing new cutting-edge technologies with a vision to push Biogen's state-of-art science in protein production and ultimately impact patient lives.This position will focus on development of high productivity and robust cell culture processes through classically and statistically designed experiments. A key objective of this role is to support increasing process robustness and productivity through comprehensive understanding of levers important to mammalian cell culture involving multiple CHO cell lines producing a variety of novel or biosimilar therapeutics including but not limited to monoclonal antibodies, fusion proteins and other complex biologics. These activities can include clone screening, early and late stage scale-up process optimization, robustness studies and process characterization. A major component of the role involves independently designing, conducting, and documenting laboratory bioreactor experiments with a focus on process definition and understanding. The role represents Cell Culture Development (CCD) at cross-functional meetings and may also lead key department initiatives or upstream process development projects. The right candidate will also contribute to technology innovation projects that utilize multi-omics tools to gain deeper understanding of biological processes, development/optimization of continuous manufacturing and evaluation of alternative hosts for low cost protein production. Candidates must be strong team players and have an ability to collaborate effectively on complex projects. A strong affinity for the laboratory with demonstrated success using those techniques is expected. A self-driven candidate will advance Biogen's culture of continued scientific innovation by proposing and executing novel ideas to solve complex problems via writing grants to get internal funding along with strong representation for Biogen at external conferences by presenting the findings.Responsibilitiesinclude:Plan, perform and document experiments at bench-scale (shake flasks, AMBR, 3L reactors, etc.) to support development of mammalian Cell Culture processes for recombinant protein production.Perform data analysis on experimental results and design future experimental studies with minimal supervision.Represent CCD while working collaboratively with team members across cross-functional teams to ensure lab experiments are well-planned and executed.Perform data analysis and troubleshooting of experiments and lab equipment.Document development work in concise reports and provide project updates via oral presentationsSupport lab maintenance tasks, lab harmonization and workflow optimizations and new technology evaluations thru innovation projects and present findings in form of scientific publications and at external conferences.Act as a mentor to fellow colleagues and junior staff.AdditionalResponsibilitiesfor Higher Level:Lead department initiatives and work independently or with minimal supervision on defined projects for development of cell culture processes with the ability to map out the overarching project timeline of activities.Engage in cross-functional program strategy discussions, helping to identify and solve end to end process and CMC technical challenges.Perform independent data analysis and interpretation. Develop strategies for optimization and troubleshooting while meeting volvement in applied process modeling (advanced math, statistics, and coding) for condition simulations.Work closely with pilot plant for process scale-up and execution of development projects.Support multi-omics project to advance biological understanding of cell culture processes and contribute to machine learning/modeling initiatives for efficient analysis of big data.QualificationsProven record of successfully planning and executing projects and experiments. Knowledge and technical experience in mammalian cell culture/ biotechnology related development including aseptic operations, cell biology, biochemistry, analytical techniques, and bioreactor operations required. Familiarity working with complex laboratory operations, instrumentation and control systems. Excellent verbal and written communication skills. Demonstrated technical proficiency and creativity in developing innovative technologies/approaches in cell culture. Excellent organizational, communication, and time management skills. Proficiency in big data analysis using Python/R, JMP, Matlab or other commercial software is a big plus.Engineer III:Bachelor's degree with 4-6 years of experience or M.S. degree with 2-4 years of experience in Bio/Chemical Engineering or related life science field of experience required.Sr.Engineer I:Ph.D. with 0-2 years or M.S. degree with 4-6 years of experience in Bio/Chemical Engineering or related life science field of experience required.Additional InformationWe are seeking a highly motivated and creative individual with bioprocess engineering experience to join our Cell Culture Development team. This position provides an exciting opportunity to develop robust, highly productive cell culture processes for production of recombinant protein biologics. We are looking for someone who is passionate for exploring novel scientific ideas and play a key role in developing new cutting-edge technologies with a vision to push Biogen's state-of-art science in protein production and ultimately impact patient lives.SummaryType:Full-timeFunction: ScienceSDL2017

Keywords: Biogen Idec, Somerville , Engineer III/Senior Engineer I, Other , Somerville, Massachusetts

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