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Research Fellow- Comander Lab

Company: Mass General Brigham
Location: Somerville
Posted on: June 4, 2021

Job Description:

DescriptionComander Research LabPOSITION SUMMARY: We are seeking a talented postdoctoral fellow to join the Ocular Genomics Institute team to study the genetic causality of and gene therapies for inherited retinal degenerations (IRDs). IRDs are important causes of vision loss that affect people of all ages. These disorders cause vision loss via dysfunction and death of the photoreceptor and retinal pigment epithelial cells of the retina. The first FDA-approved gene therapy for an inherited disease was for an IRD, and gene therapies for several specific genetic forms of IRD show promise in clinical trials. Our research uses the latest techniques in genome editing and in functional genomics to address challenges in developing new therapies and in understanding the genetic basis of Mendelian disease. We are looking for a postdoc to join our NIH- and foundation-funded projects: 1) Many disease genes are too large to be delivered using current vector technology. You can join our program to develop and translate genome editing tools to treat IRDs in situ, including using base editing tools. 2) To take advantage of a gene therapy, a correct genetic diagnosis is needed among the >200 IRD disease genes which have been identified to cause retinal disease, but the genetic cause of disease remains elusive for ~1/3rd of affected patients. You can join our program to design and implement high throughput assays for the characterization of DNA variants of unknown significance to determine which variants are disease-causing (functional genomics) and increase the diagnostic rate of genetic testing. ESSENTIAL FUNCTIONS: Read, analyze and summarize published literature Design and execute in vitro and in vivo Undertake relevant coursework if required by mentor. Attend relevant meetings Meet regularly with mentor to review project progress and milestones Plan and deliver a seminar on the project Take administrative (inventory, purchasing, etc. ) responsibilities in the lab when necessary Write a final report or submit a manuscript to a peer-reviewed journal describing the project and results QualificationsEDUCATION AND EXPERIENCE: Doctoral degree (MD or PhD) with more than 1 year of lab experience. WORKING CONDITIONS: Lab setting. PHYSICAL REQUIREMENTS: Possible lifting of 10 to 20 lbs., depending on nature of chosen project(s).EEO StatementMassachusetts Eye and Ear is proud to be an equal-opportunity employer and is committed to providing a workplace free from harassment or discrimination. All employment decisions are made without regard to race, color, age, gender, gender identification, sexual orientation, religion, marital status, sex, pregnancy or conditions related to pregnancy, national origin/ancestry, citizenship, disability, military status, genetic information, or any other basis prohibited by law. These protections extend to all management practices and decisions, including recruitment and hiring practices, appraisal systems, promotions, training, and career development programs

Keywords: Mass General Brigham, Somerville , Research Fellow- Comander Lab, Other , Somerville, Massachusetts

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