Scientist I/Computational Biology

Company: Takeda
Location: Somerville
Posted on: January 5, 2022

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's Privacy Noticeand Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionScientist I/Computational Biology Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine?-- Join us as a Scientist I/Computational Biology --in our--Cambridge, MAor San Diego, CA office.At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.Here, you will be a vital contributor to our inspiring, bold missionOBJECTIVES/PURPOSEAnalyzing and interpreting high dimensional molecular data for the development of GI TherapeuticsIdentifying and developing sophisticated computational biology approaches to identify targets and provide translational medicine hypotheses.Generate data insights to drive GI projects, Interface with research teams and support the data analysis and interpretation needs of GI projectsDrive collaborations with internal groups, external partners, including CROs and academia for data analysis and machine learning.ACCOUNTABILITIESSupport GI discovery teams to identify novel drug targets and achieve translational medicine objectives using sophisticated computational biology techniques.Interact closely with biologists in the GI DDU to design experimental studies, plan analyses, data integration and data interpretation.Identify, build, and use bioinformatic pipelines to process and QC other omics data types including genomics, transcriptomics, single cell sequencing.Interpret preclinical and clinical datasets using appropriate statistical methods.Create visualizations, interpret high dimensional data and explain results to cross-functional teams.Perform integrative analyses with multi-omics datasets, identifying novel targets and achieving translational medicine goals.Develop machine learning algorithms, including deep neural network algorithms.Independently conduct data analysis tasks within a project scope, exercising judgement to evaluate a variety of statistical factors.Independently keep abreast of current literature computational biology for drug development.Maintain and share code.Plan and coordinate computational biology activities internally and in partnership with external CROs and academic partners, including complex projects requiring multiple members of the team and organization.Prepare and present comprehensive scientific reports to a full range of internal and external audiences.Work collaboratively with data scientists and data engineering groups to enhance our computational infrastructure, user interface, query and visualization capabilities.Process, QC and analyze microbiome datasets (16S and shotgun metagenomics)EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLSPhD degree with Post Doc experience, or equivalent.or Master's degree in a scientific discipline, or equivalent with 7 + years experienceor Bachelors degree in a scientific discipline, or equivalent with 10+ years experience,Knowledge of and experience with machine learning and bioinformatic techniques.Experience with high dimensional data analysis derived from Next Generation Sequencing, including some of the following: microbiome data, RNASeq, DNASeq, miRNA, copy number, epigenetics, and single cell sequencingHands-on experience developing and implementing bioinformatic pipelines for Omics datasets.Solid knowledge of Unix/Linux, command line interfaces, and fluency in some common scripting and/or programming language (e.g., R, Python, Perl, Java, C / C++).Familiarity with parallel computing, relational databases (e.g., SQL) and cloud computing or distributed computing (i.e. AWS)Familiarity with Tensorflow/Keras or equivalent deep learning languageTheoretical knowledge of bioinformatics, computational biology; Keeps current with emerging trends in bioinformatics and computational biologyFamiliarity with popular public domain data sources and programmatic interfacesExperience with group and program leadership for assigned programs to help design and direct computational biology activities to meet program objectives; able to provide input on timelines and resource needs as indicatedIn-depth knowledge of currently assigned computational methodsBasic knowledge of science/technology outside specific disciplineStrong scientific understanding of molecular biology and genomicsSupportive of team-based research and able to work effectively in a matrix organizationVACCINATION REQUIREMENTS:Effective November 1, 2021, absent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. As of the same date, absent an approved religious or medical reason, US field-based employees, employees must be fully vaccinated in order to continue in their current roles.-- US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. Candidates are encouraged to speak with their recruiter to seek further information on the applicable guidelines for the Business Unit/Function for which they have applied.WHAT TAKEDA CAN OFFER YOU: 401(k) with company match and Annual Retirement Contribution PlanTuition reimbursement Company match of charitable contributionsHealth & Wellness programs including onsite flu shots and health screeningsGenerous time off for vacation and the option to purchase additional vacation daysCommunity Outreach ProgramsEmpowering Our People to ShineDiscover more at takedajobs.comNo Phone Calls or Recruiters Please.EEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsBoston, MAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time

Keywords: Takeda, Somerville , Scientist I/Computational Biology, Other , Somerville, Massachusetts