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Senior Scientist Discovery Toxicology

Company: Takeda Pharmaceutical
Location: Somerville
Posted on: September 22, 2022

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's and . I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionAbout the role:

  • As part of the Global Discovery Toxicology Team work in interdisciplinary teams within and across Global Safety to provide safety support to early discovery and development teams in Immuno-oncology and Rare Diseases as well as engage in core activities within the Discovery Toxicology group
  • Work as part of a team of safety assessment scientists and more broadly DMPK, pathology, pharmacology, and medicinal chemistry experts to implement discovery toxicology strategy to enable the selection and progression of optimized drug candidates
  • Apply novel toxicity mechanism-based assays and integrated models to support early target safety and chemistry evaluation.
  • Career development opportunities exist to represent Preclinical Safety on internal and external scientific working groups and committees.Join Takeda as Senior Scientist, Discovery Toxicology, based in Cambridge, MA.How you will contribute:ACCOUNTABILITIES
    • Provide pharmaceutical drug project teams with expert advice and direction to improve the quality of therapeutics selected for further development based on proactive risk assessment of target-, platform- and chemotype-related toxicities.
    • Develop comprehensive target safety reviews with risk mitigation plan for early drug discovery project teams based on literature, bioinformatics, and other predictive tools.
    • Apply state of the art in silico, in vitro, and in vivo de-risking strategies to aid in the selection and optimization of large and small molecule therapeutics, as well as new therapeutic modalities
      • Lead the development of early hypothesis-driven investigation into mechanisms of toxicity for the proactive management of potential safety liabilities and communication of impact to teams
        • Responsible for effective management and utilization of resources to maximize the team's impact on Takeda's pipeline
        • Fosters positive and effective team culture and builds/evolves departmental infrastructureMinimum Requirements/Qualifications:
          • Minimum of BS + 11 yrs experience equivalency or MS/PharmD with 9+ years of pharmaceutical experience or PhD in a scientific discipline and 3+ years of experience working at a pharmaceutical company
          • Experience in the drug discovery process from the pharmaceutical industry, with an understanding of scientific partner lines outside of safety and toxicology
          • Demonstrated project team experience at a pharmaceutical company and ability to work effectively in a matrix, global environment as part of a multidisciplinary team
          • Strong problem solver who is highly organized with the ability to thrive in an environment with rapidly changing priorities.
          • Broad scientific knowledge including pharmacology, toxicology, physiology, immunology and biochemistry.
          • Experience in development across mixed modalities, especially cell and gene therapy and knowledge of immuno-oncology and/or rare diseases is desired.
          • Knowledge of the common technical document (CTD) and early regulatory process is a plus.
          • Strong interpersonal skills with an ability to develop solid, long term relationships and the ability to influence others, and adept at working across multiple cross-functional areas.
          • Excellent oral and written communication skills
            • DABT certification a plus, but not necessaryWhat Takeda can offer you:
              • Comprehensive Healthcare: Medical, Dental, and Vision
              • Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan
              • Health & Wellness programs including onsite flu shots and health screenings
              • Generous time off for vacation and the option to purchase additional vacation days
              • Community Outreach Programs and company match of charitable contributions
              • Family Planning Support
              • Flexible Work Paths
              • Tuition reimbursementMore about us:At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.EEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsBoston, MAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time

Keywords: Takeda Pharmaceutical, Somerville , Senior Scientist Discovery Toxicology, Other , Somerville, Massachusetts

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