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Scientist I, Cell Biology, GI DDU

Company: Takeda Pharmaceutical
Location: Reading
Posted on: September 23, 2022

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge. Job Description About the role: At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.Join Takeda as a Scientist I where you will engineer cells by designing and implementing strategies to knockdown or express genes of interest. You will also design and perform phenotypic characterization analysis: flow cytometry, immunofluorescence, gene expression, protein secretion. As part of the Cell Therapy Product Development Research team, you will report to the Head of Cell Therapy Product Development Research, and work with the Gastroenterology Drug Discovery Unit (GI DDU) organization. How you will contribute:

  • Culture and differentiation of primary cells (e.g, isolated from blood or tissue), cell lines, and iPSCs
  • Engineer cells by designing constructs and transfecting cells to express or suppress genes of interest
  • Characterize cells by flow cytometry, qPCR, immunofluorescence, MSD, ELISA, scRNA-seq
  • Develop and validate cell-based functional assays using platforms like Incucyte
  • Design, troubleshoot, and develop SOPs
  • Detailed record keeping of data, samples inventories, and cell banks
  • Analyze experimental data using standard software packages
  • Communicate experimental results to team members within and between groups across sites
  • Manage a small team of associate scientists Minimum Requirements/Qualifications:
    • PhD in a scientific discipline (or equivalent)
    • MS in a scientific discipline (or equivalent) with 4+ years relevant experience, or
    • BS in a scientific discipline (or equivalent) with 6+ years relevant experience
    • Degree in cell biology, molecular biology, stem cell biology, developmental biology, genetics, or related field of science
    • 3+ years of cell engineering experience
    • 3+ years of hands-on experience with iPSC culture methods
    • Experience using common software packages to analyze data sets (GraphPad Prism, Excel, FlowJo)
    • Experience in immunology and immune cell culture is desirable
    • Experience isolating cells from blood or tissue for culture is a plus
    • Experience with direct differentiation of human cells to terminal cell types is a plus
    • Experience with development and validation of cell-based or molecular assays is a plus What Takeda can offer you:
      • Comprehensive Healthcare: Medical, Dental, and Vision
      • Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan
      • Health & Wellness programs including onsite flu shots and health screenings
      • Generous time off for vacation and the option to purchase additional vacation days
      • Community Outreach Programs and company match of charitable contributions
      • Family Planning Support
      • Flexible Work Paths
      • Tuition reimbursement More about us: At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law. Locations Boston, MA Worker Type Employee Worker Sub-Type Regular Time Type Full time

Keywords: Takeda Pharmaceutical, Somerville , Scientist I, Cell Biology, GI DDU, Other , Reading, Massachusetts

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